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2.3 Failure of antioxidant system Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates cellular antioxidant defense by directly regulating glutathione (GSH) biosynthesis and GPX4 expression through transcriptional control of Glutamate-Cysteine Ligase Catalytic Subunit(GCLC)/ Glutamate-Cysteine Ligase Modifier Subunit(GCLM) and GPX4 (Fan et al., 2024)

B12 is naturally found in animal products such as meat, liver, fish and eggs

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The review documented DSIP's widespread distribution throughout the brain and peripheral tissues, its remarkably stable presence in cerebrospinal fluid, and its unusually long-lasting biological effects despite a short plasma half-life of only minutes