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Conversely, M2-polarized macrophages secrete cytokines such as IL-10 and TGF-, which activate anti-ferroptotic signaling cascades within tumor cells

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Nova Science, Hauppauge, pp 197-220

This would be especially true where there is insufficient intrinsic factor produced and/or where the ileum of the small of the intestine is no longer present or able to absorb the vitamin B12/intrinsic factor complex
