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While acute alcohol use has been shown to impair production of proinflammatory cytokines such as TNF- and IL-1, which may predispose patients to pneumonia, chronic alcohol use has associated with increased levels of proinflammatory cytokines, such as TNF-, IL-1, and IL-6, in both human and animal studies

Direct interaction between Nrf2 and p21Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response

The ratio of reduced glutathione (GSH) to its oxidized form (GSSG) serves as a fundamental marker of the intracellular redox environment

The typical patient will have an immediate reduction in dullness and enjoy smoother complexion, says Svendsen