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When both glutaminolysis and glycolysis are simultaneously blocked, ROS accumulate, triggering AMPK activation and apoptosis in cancer cells [239]

This interrelationship suggests there may be cross-talk between H 2 S and NO (207,208)

Oxid Med Cell Longev 2023(1):9808100 Zhang G et al (2024) Silibinin induces both apoptosis and necroptosis with potential anti-tumor efficacy in lung cancer