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Figure 3 shows how fatty acid metabolism, oxidative phosphorylation, and the citric acid cycle within the mitochondrion intersect with glycolysis and fatty acid synthesis

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Unfortunately, NAD+ levels decline with age, stress, poor diet, and metabolic dysfunction

Advanced biomaterials and smart delivery systems (e.g., pH-sensitive matrices or stimuli-responsive hydrogels) are under investigation to address this, but their translation to clinically approved products remains still restricted
