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Description
In APCs, CD80 interacts with PD-L1 in cis to disrupt PD-L1/PD-1 interaction between APCs and T cells, limiting the PD-1 coinhibitory signal, while promoting CD28/CD80 interactions and enhancing T cell activation (213)
ACSL 4 , Acyl CoA synthase long-chain family member 4
As such, our preliminary studies suggest that the ability of JHU083 to downmodulate C/EBP protein and thus the expression of CSF3 may be due in part to the ability of JHU083 to promote autophagy
10.3389/fcell.2022.1011435 13
