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Several events seen in the brain of neurodegenerative diseases could give rise to an abnormal production of reactive oxygen spices (ROS)
Intestinal pathophysiologic changes that may be modified by glutamine in SCD include increased intestinal permeability and increased translocation of bacteria into the systemic circulation promoting ongoing inflammatory processes that activate blood cells and platelets involved in the development of VOC

A systematic review and meta-analysis evaluated the dose-response relationship between folate intake and changes in blood biomarkers

Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity