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20,38,39 Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNA regulation, also play a critical role in regulating gene activity and impacting MTX metabolism and toxicity

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When administered through controlled medical protocols, glutathione may influence melanin pathways by inhibiting the enzyme tyrosinase and shifting melanin synthesis toward lighter pigments

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Seed priming with JA maintains RWC, chlorophyll pigments, soluble proteins, soluble sugars, and proline content RWC under Na 2 CO 3 stress significantly declined by 21.99% at 100 mM Na 2 CO 3 , but the maximum decline of 31.65% in RWC was recorded at 150 mM Na 2 CO 3 compared with that of the untreated control (Fig

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Many of the difficulties of any such investigation can be overcome by studying a larger sample size of patients

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