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20,38,39 Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNA regulation, also play a critical role in regulating gene activity and impacting MTX metabolism and toxicity

When administered through controlled medical protocols, glutathione may influence melanin pathways by inhibiting the enzyme tyrosinase and shifting melanin synthesis toward lighter pigments

Seed priming with JA maintains RWC, chlorophyll pigments, soluble proteins, soluble sugars, and proline content RWC under Na 2 CO 3 stress significantly declined by 21.99% at 100 mM Na 2 CO 3 , but the maximum decline of 31.65% in RWC was recorded at 150 mM Na 2 CO 3 compared with that of the untreated control (Fig

Many of the difficulties of any such investigation can be overcome by studying a larger sample size of patients