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Phase II clinical trials of this inhibitor have been completed for patients with ovarian cancer and myelodysplastic syndrome (NCT01822691, NCT01685255)
As the metabolomics results showed that the serum levels of several amino acids were disturbed in the LPS group, LPS-induced acute liver and kidney injury were clearly associated with the alterations in amino acid metabolism (Table 1)
MARINELLO, A.J., GURTOO, H.L., STRUCK, R.F., & PAUL, B

[DOI] [PMC free article] [PubMed] [Google Scholar] Maulucci G., Pani G., Labate V., Mele M., Panieri E., Papi M., Arcovito G., Galeotti T., De Spirito M