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The aging process is marked by a persistent dysregulation between pro-oxidant and antioxidant mechanisms, resulting in the excessive production of ROS that hinder eNOS functionality, diminish NO bioavailability, and exacerbate endothelial dysfunction (19)

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The drugs and doses for the treatment of AF are listed in Table 2

Kirkland AE, Baron M, VanMeter JW, Baraniuk JN, Holton KF
