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Mechanistically, folic acid supplementation helps in mitigating the elevated HCY levels characteristic of several neurodegenerative diseases by accelerating the remethylation pathway (dependent on vitamins B12 and folate)
however, it improved pain scores in patients with DPN in a phase 2 study
The branched-chain amino acid leucine supported chondrocyte proliferation and hypertrophy in both mTOR-dependent and -independent mechanisms, whereas glutamine was necessary for adequate protein synthesis in chondrocyte cultures
Cryo-EM grid preparation was similar for all samples
