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Previous studies identified an activating mutation within the ligand binding domain of NHR-49 at valine 411 where this hydrophobic valine was mutated to a charged glutamic acid 54,55

3 Endocrinology / Metabolism ReviewIGF-1 receptor signalling, insulin-like metabolic effects and glucose handling

Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction

To create a hypertonic medullary interstitium, adequate function of all the tubular sodium transporters is necessary, for example, NHE3 (type 3 Na+/H+ exchanger), NaPi-2, (type 2 Na-Pi cotransporter), BSC-1 (type 1 bumetanide-sensitive Na-K-2Cl cotransporter), or TSC (thiazide-sensitive cotransporter) in the lumen side of the tubule (mechanism 1)