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The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD

This study of 232 Chinese diabetic patients demonstrates that acetyl-L-carnitine was as effective as methylcobalamin (a current treatment choice in China) in reducing neuropathic pain

These approaches offer promise for safer, more targeted, and more effective management of heavy metal toxicity

It is a subject of in-vitro study into copper-peptide coordination chemistry and cellular-matrix biology