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I've also done a lot of research about PA since being diagnosed and I was a patient of one of the research consultants Mr Pritchard until last summer
The driving force behind this combination is the hypothesis of synergy

N Engl J Med 2013;369(14):13061336

Proteinligand interactions, including hydrogen bonds (distance cutoff 3.5 , angle 120), hydrophobic contacts, and -stacking interactions, were analyzed and visualized using PyMOL 2.5 (Schrdinger, 2023)
