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The integrin binding activity has a specific role in facilitating dissemination and extravasation of the spirochete out of the vasculature and into perivascular connective tissue but is not essential for murine infection (Kumar et al., 2015

For monocytes, TGF- has been shown to function as a chemoattractant as well as an upregulator of anti-inflammatory response

Preclinical data suggests AOD9604 shifts the metabolic balance toward burning fatty acids for energy rather than storing them, with effects observed particularly in visceral adipose tissue

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