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For example, methapyriline increases liver weight and the number of hepatocyte mitochondria in treated mice, with development of hepatotoxicity and liver neoplasia probably secondary to oxidative damage (Powell et al

[DOI] [PubMed] [Google Scholar] 61.Ungheri D, Pisani C, Sanson G, et al

According to a clinical study reported in Korea in 1977, out of 150 patients with melasma who took 50100 mg of glutathione orally three times a day for 6 weeks on average, 74.1%, 56.7%, 7.3%, and 18.6% showed excellent, good, fair, and no improvement, respectively [111]