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Similarly, in STZ-induced diabetic rats, betaine inhibited oxidative stress and inflammation while activating the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway to enhance cognitive impairment (69) (Figure 4E)

It is noted that, under the conditions of a prolonged pro-inflammatory status, ROS can activate kinases such as the IKK complex (composed of two kinases, IKK and IKK, and the regulatory subunit NEMO/IKK)

doi: 10.3390/ijms19020462

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