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The treatment with biomimetic HAP showed statistically significant skin roughness reduction, skin elasticity and firmness increases (results summarized in figure 3)

The effectiveness of substances applied on the surface of the epidermis depends on their ability to penetrate the stratum corneum

Requirements of vitamin B 12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation