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Morton J, McLaughlin DM, Whiting S, Russell GF

Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: Potential role of attenuated oxidative stress and altered contractile protein expression

Hypotheses It was hypothesized that: MTX administration will induce significant hepatotoxicity, characterized by: Increased liver injury scores in histopathological examinations (necrosis, inflammation, and hepatocellular degeneration), Elevated expression of oxidative stress and metabolic markers (CD38 and GLUT1) in immunohistochemical analyses, Upregulation of pro-apoptotic BAX and downregulation of anti-apoptotic BCL2 mRNA levels, reflecting enhanced apoptotic signaling

Es decir, estamos ante una sustancia que nuestro organismo genera por s mismo de forma natural, como ocurre con otros muchos suplementos