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Other key proteins in the autophagy pathway regarding the kidney have also been investigated

While LNCaP and MDA-PCa-2b cells have largely conserved biological and molecular responses to acute IL-1 signaling, including upregulation of NF-kB signaling and downregulation of cell proliferation, they have also evolved conserved and distinct molecular responses to chronic IL-1 signaling that may support or promote tumor progression [48]