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Description
Upon intranasal administration, Methylcobalamin is rapidly absorbed through the nasal mucosa and enters the bloodstream, where it acts as a cofactor for enzymes involved in DNA synthesis and methylation
389 GSK-J1 is a specific JMJD3 inhibitor 390 that can affect the demethylation of histone H3K27me3, regulate Th17/Treg cell differentiation, suppress the secretion of inflammatory factors, and improve the intestinal mucosal immune dysfunction caused by DSS in experimental acute UC model mice
The present study lacks an assessment of immune cell changes

doi: 10.1016/j.jot.2017.03.005
