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As expected, bioinformatic analysis revealed that phosphotyrosine sites activated by EGF stimulation were enriched for proteins annotated with the EGFR signaling pathway gene ontology term ( P 1 indicates an antagonistic effect

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[DOI] [PMC free article] [PubMed] [Google Scholar] Paszek M, DuFort C, Rossier O, et al

6 The potential of ferroptosis in PD early diagnosis It is estimated that by the time motor deficits are detected and individuals with PD receive a clinical diagnosis, they may have lost 3050% of their dopaminergic neurons, accompanied by a 5060% reduction in striatal dopamine (212), underscoring the critical need for early diagnosis in PD treatment