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2 In addition to the serious risks of addiction, abuse, and overdose, the use of prescription opioids can have a number of side effects, even when taken as directed: Tolerancemeaning you might need to take more of the medication for the same pain relief Physical dependencemeaning you have symptoms of withdrawal when the medication is stopped Increased sensitivity to pain Constipation Nausea, vomiting, and dry mouth Sleepiness and dizziness Confusion Depression Low levels of testosterone that can result in lower sex drive, energy, and strength Itching and sweating Fentanyl is a synthetic opioid pain reliever

Her baseline Clinical Disease Activity Index (CDAI) score was calculated to establish a target for tight disease control (Moreland & Cannella, 2026)