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The PCL component forms a hydrophobic core that encapsulates shikonin, while the PEI segment is employed for loading PD-L1 siRNA

Lastly, secondary lesions associated with AS, including calcification and atheromatous ulcer formation, can further exacerbate vascular damage and elevate the risk of cardiovascular and cerebrovascular diseases 24

Specifically, these strains (such as LP-0291 and LF-DR9) can reduce the expression of the p53 gene in local gastrocnemius and tibialis muscles, which is associated with the activation of AMPK

[DOI] [PMC free article] [PubMed] [Google Scholar] Higgins 2005 Higgins JPT, Green S, editors