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[DOI] [PMC free article] [PubMed] [Google Scholar] Khan S

identified mitophagy as an intrinsic vulnerability in CRC cells subjected to statin treatment, revealing how disruption of mitochondrial homeostasis, shaped by distinct metabolic contexts, leads to cell death and therapeutic sensitivity [103] Spatial heterogeneity across colorectal tumor sites underlies distinct metabolic phenotypes [104]

Numerous in vitro and in vivo , experimental studies have demonstrated that itexhibits a significant inhibitory effect on the proliferation of various tumor cells ( Astragalus also plays a role in modulating tumor blood vessels

One of the theories that tries to explain the exercise effects defends that it may be in part due to the accumulation of oxidative damage induced by reactive oxygen species (ROS) and reactive nitrogen species (RNS) to cells and macromolecules [13]