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Current strategies for brain drug delivery
Data from the Minnesota Green Tea Trial showed a 6.7% incidence of ALT elevation in postmenopausal women consuming 843 mg/day EGCG, with polymorphisms in the COMT and UGT1A4 genes contributing to interindividual variability in toxicity (245)
In addition, CB-839 has been extensively studied in hematological malignancies such as acute myeloid leukemia (AML) (Gregory et al., 2019), myelodysplastic syndrome (MDS) (Okabe et al., 2022), and multiple myeloma (MM) (Das et al., 2014)
Long S, Goldblatt J
