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The objective function equation (1) is to minimize the deviation of the computational flux rates from the measured flux rates

Glutathione operates through multiple mechanisms: Directly neutralizing reactive oxygen species, [1] Regenerating other antioxidants like vitamins C and E, [2] Supporting the body's natural detoxification processes

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As research continues to advance, the combination of ferroptosis with existing therapies, such as chemotherapy, immunotherapy and targeted treatments, holds great potential for improving the prognosis and survival rates of PDAC patients