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Introduction Glutathione S -transferases (GSTs) are phase II metabolic isozymes, found mainly in the cytosol

With the development of mass spectrometry technology, mass spectrometry-based proteomics, and metabolomic methods have gradually become powerful tools for exploring biomarkers

PubMed , Selenium | Linus Pauling Institute | Oregon State University

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux