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Imaging was done instantly in the warm Tyrodes buffer

Oncogene (2006) 25(42):5787800.10.1038/sj.onc.1209576 8 ChenDLiuJRuiBGaoMZhaoNSunSet alGSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation

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While, historically, desensitization has referred to blockade of G protein coupling and second messenger responses, it is now clear that GPCRs can also signal via -arrestins independent of G proteins and even signal via -arrestin- and G protein-dependent mechanisms that are not fully understood