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10.1093/gerona/glz080 26 KoningT
& Odomi, M
If it is unregulated, free radicals can create oxidative stress, which leads to damage in our cells and contributes to health problems ranging from heart disease to dementia
The impact of TXNIP on ferroptosis seems to be manifold, as it downregulates SLC7A11 and GPX4 levels [108,122] , increases the labile iron pool via NCOA4-mediated ferritinophagy [123,124] , and disrupts GSH synthesis (Figure 3) [112]
