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The available evidence indicates that there is a notable impairment in endothelial-derived nitric oxide (NO)-mediated vasodilation in individuals with both insulin-dependent and non-insulin-dependent diabetes mellitus (91)

In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

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