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Figure 4 Table 3 List of mechanisms of resistance to anti-angiogenic therapies and ways to target them along with the outcomes associated with each approach

The gradual increase lets your body adapt to triple-receptor activation incrementally, reducing side effects that would be severe at full dose from day one

Let the alcohol do its job

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study