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10.1038/onc.2012.67 52 YangY.YouX.QuanY.LuoS.LiL.ZengJ.et al

As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine

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A: Not officiallythey are approved for Type 2 diabetes and weight management