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15 week old ZDF rats displayed hyperglycemia, MNCV and SNCV deficits, thermal and mechanical hypoalgesia, tactile allodynia, and 26% loss of intraepidermal nerve fibers

Common clinical features in all three syndromes that result from mutations in the insulin receptor gene including severe insulin resistance, acanthosis nigricans and hyperandrogenism (the latter being observed only in females)

This general rule applies to maintaining consistent supplementation schedules for vitamins)