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Syntheses of acyclic nucleoside phosphonates (ANPs) are based on several alternative approaches: 1) preparation of N -(hydroxyalkyl) derivatives of purine or pyrimidine bases followed by introduction of the phosphonomethyl residue, 2) alkylation of the nucleobase with an appropriate synthetic precursor, usually dialkyl ester of phosphonomethoxyalkyl halide or tosylate, 3) ring-closure reactions of some aminoalkylphosphonates forming appropriate heterocyclic base moieties (preparation of aza and deazapurine ANPs) and 4) transformation of reactive functional groups at the side chain or in the heterocyclic base in a previously prepared phosphonate (Hol, 2003)

The cause of death was neonatal CPT II deficiency