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doi:10.2165/00003495-197816010-00002

Therefore, Yu et al fused red blood cell membranes with fibroblast-like synoviocyte membranes (RFM) to modify Prussian blue nanoparticles (PB NPs) loaded with Schisanlactone E (SE), and chemically modified hyaluronic acid was grafted onto the RPS NPs through DSPE-PEG2000-NH2 to create a multifunctional nanodelivery system (HA@RFM@PB@SE, HRPS NPs) 179 (Figure 10)

Alzheimers disease as a membrane disorder: spatial cross-talk among -amyloid peptides, nicotinic acetylcholine receptors and lipid rafts

It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)
