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In the Ozempic trials for type 2 diabetes, approximately one in twelve participants reported diarrhoea

Tirzepatide causes thyroid C-cell tumors in rats, and although its unknown whether tirzepatide causes thyroid C-cell tumors in humans, it is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

[DOI] [PMC free article] [PubMed] [Google Scholar] Sen A, and Hoffmann HM (2020)