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Description
Painful diabetic neuropathy, or PDN, is more than just discomfortits a major barrier to quality of life
Moreover, insulin degrading enzyme (IDE) and biliverdin reductase-A (BVR-A) are the two enzymes associated with insulin signaling that appear to be increasingly oxidized during progression of AD, thus promoting BIR (402, 404406)
We can consider the latter as a model of oxidative stress induced cell damage, even though it differs from the other studies due to the absence of exogenous toxic substances
(PubMed) Hart AM, Wilson AD, Montovani C, et al
