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Thus, albeit initially the concerns on the use PDE5i for CAD treatment - due to the marginal beneficial effects - shifted their application from CVD to ED, thereafter, sildenafil was reallocated for the treatment of cardiac disorders, due to both endothelial and anti-inflammatory/pro-remodeling effects in cardiac cells (43)

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Pharmacodynamics of M6G M6G selectively binds the MOP with a potency similar to that of morphine [109, 110], and its efficacy is thought to be equal to or slightly higher than that of morphine [86, 111]

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