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EMBO J 26:14341443 Dempsey DA, Vlot AC, Wildermuth MC, Klessig DF (2011) Salicylic acid biosynthesis and metabolism

For reference data on compounds, see the peptide research database

Autoimmune Progesterone Dermatitis (APD) also known as progestogen hypersensitivity is a rare immune-mediated reaction in which the body mounts an allergic or autoimmune response to endogenous progesterone or synthetic progestins, leading to cyclical skin and systemic symptoms that worsen during the luteal phase of the menstrual cycle
Crystal structures indicate that the His-51 deprotonates the nicotinamide ribose, which deprotonates Ser-48
