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Description
In eukaryotic cells, ISA can react with the sulfhydryl group of GSH (Figure 1) and decrease the intracellular GSH, incurring an oxidative stress that is toxic to cells (Xie et al., 2023)
Boyer, P
501 Activation of Nrf2 prevents ferroptosis by upregulating ferritin, SLC7A11 and GPX4
Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients
