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For example, many NSAID prodrugs, synthesized by coupling an antioxidant moiety through amide linkage, as well as several mutual prodrugs (both moieties are pharmacologically active) made with naturally found phenolic antioxidants including guaiacol, thymol, eugenol and other alcoholic compounds have yielded gastro-sparing results
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9 In addition, the redox potentials of the mitochondrial and cytosolic NADP(H) systems are the same around400 mV in the liver
