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Genetic and environmental interplay : mutations in SNCA , LRRK2 , PINK1 , and VPS35 interact with toxins and metabolic stressors to trigger degeneration

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In amphetamine-induced stereotypy models (a pre-clinical model of schizophrenia-like conditions), DSIP normalised brain metabolism and MAO activity disrupted by long-term amphetamine treatment, establishing a role for adrenergic system normalisation as a mechanism of DSIPs neuroprotective activity