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Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123

This paper remains a landmark reference because it established that selective GHS-R1a agonism could achieve tissue-level anabolic outcomes comparable to less selective secretagogues while maintaining a more favorable endocrine side-effect profile in research models

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Prebiotic lactulose ameliorates the cognitive deficit in Alzheimers disease mouse model through macroautophagy and chaperone-mediated autophagy pathways