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Description
A double-blind, placebo-controlled clinical trial in which participants received validated neuropsychological tests before and after treatment with Ginkgo biloba extract indicated significant improvement in working memory and information processing speed [186]

Key Safety Differentiators No IGF-1 elevation: AOD-9604 does not stimulate IGF-1, meaning it avoids risks such as organ/tissue overgrowth or acromegaly No glucose disruption: Clinical data shows it does not impair insulin sensitivity or worsen blood sugar regulation Comparable to placebo: In obesity trials, the incidence of adverse effects was similar to placebo groups, underscoring its tolerability Legal Status of AOD-9604 United States: AOD-9604 is not FDA-approved as a drug, dietary supplement, or weight loss therapy

Pickart compares this resetting effect to how a piano must be periodically fine-tuned to maintain melodic balance

Post-marketing surveillance depends on voluntary reporting and is designed poorly to detect gradual, cumulative effects
