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Suppressed oxidative distress in those cases may have a negative impact on health

The observed threshold effect at 358.7 pg/mL (OR = 1.04 per 10 pg/mL, 95% CI: 1.001.08, P = 0.03) suggests a plateau in B12 benefit beyond this level, likely due to saturation of methionine synthase activitya mechanism consistent with non-linear enzymatic dose-response relationships, where additional B12 may not enhance methylation capacity [21]

[DOI] [PMC free article] [PubMed] [Google Scholar] (373).Ward VCA

Since 2000, 33 non-insulin peptide drugs have received approval worldwide
