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Early reports found a high prevalence of immunoglobulin deficiency (9/13), mainly IgA, respiratory and viral infections, CVID in some cases, and normal T cell immunity among the Wolf-Hirschhorn syndrome patients, but these early reports lack detailed genetic information (208, 209)

In our EBOV polymerase structure, the positions of the priming and intrusion loops and the supporting helix are similar to those of other nsNSV polymerase structures in the elongation state 36 , suggesting that the structure we obtained also belongs to the elongation state

There is also a reason the combination is difficult to test cleanly: because both compounds act on overlapping repair pathways (angiogenesis, cell migration), a study of the two together struggles to attribute any observed effect to either one

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