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Chinese Herbal Monomers (HMs) and Their Derivatives: Mechanisms The therapeutic mechanism of HMs involves reducing inflammatory and vascular growth factor levels, regulating Ca 2+ and K + channels, restoring mitochondrial function, and controlling signaling pathways to achieve pulmonary artery vasodilation, protect endothelial function, and reverse PVR

In ME/CFS and Long COVID, a phenomenon often referred to as the "mitochondrial doom loop" occurs

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Interestingly, some recent studies determined that the endothelial cell-derived exosomes indeed contained MT proteins responding to cellular stress conditions and EVs from various cells or human samples exhibited the presence of zinc transporters as well 111