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2.2 Major physiological changes to account for the disease pathology of -synuclein Misfolding of -synuclein has been linked to a plethora of cognitive ailments arising from the death of dopaminergic neurons and collectively referred to as synucleinopathies

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Two forces are exerted on the particle, one F E , the force exerted on the charged particle by the field, which is in the direction of the motion (toward the cathode), and the other, F f , the frictional force on the charged particle, which retards its motion toward the cathode, and hence is in the direction opposite to the motion (toward the anode (+) electrode)

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