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Science 317 (5837), 516519

HNF4-negative liver cancer lines are resistant to MCR To evaluate the possible functional impacts of altered SAA metabolism in mesenchymal liver cancer cell lines, we compared the responses of two mesenchymal liver cancer lines, SNU449 and SNU475, to methionine restriction with those of three epithelial cell lines Huh7, Hep3B, and HepG2

Zhao J, Dong X, Hu X, et al
163165 AA is the main substrate of both isoforms, but LA is a known competitive substrate and inhibitor of prostaglandin formation by COX-1 and COX-2
